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Aimin Zhou Selected Research

2-5A-dependent ribonuclease (RNase L)

1/2020RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.
12/2014RNase L contributes to experimentally induced type 1 diabetes onset in mice.
10/2014RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry.
1/2013Lack of RNase L attenuates macrophage functions.
10/2012The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization.
1/2007Tumour suppressor function of RNase L in a mouse model.
10/2005Mapping of the human RNASEL promoter and expression in cancer and normal cells.
5/2003RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.
1/2003Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways.
1/2002Skin allograft rejection is suppressed in mice lacking the antiviral enzyme, 2',5'-oligoadenylate-dependent RNase L.

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Aimin Zhou Research Topics

Disease

16Neoplasms (Cancer)
01/2020 - 01/2002
6Virus Diseases (Viral Diseases)
01/2020 - 01/2002
3Prostatic Neoplasms (Prostate Cancer)
10/2019 - 09/2007
3Ovarian Neoplasms (Ovarian Cancer)
05/2009 - 01/2002
1Body Weight (Weight, Body)
12/2021
1Fever (Fevers)
01/2021
1Fatigue
01/2021
1COVID-19
01/2021
1Cough
01/2021
1Lewis Lung Carcinoma
01/2020
1Pneumonia (Pneumonitis)
01/2020
1Fibrosis (Cirrhosis)
01/2020
1Acute Lung Injury
01/2020
1Liver Neoplasms (Liver Cancer)
09/2019
1Type 2 Diabetes Mellitus (MODY)
11/2018
1Starvation
02/2018
1Dyspepsia (Indigestion)
10/2017
1Pathologic Processes
09/2015
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
12/2014
1Infections
10/2014
1Intellectual Disability (Idiocy)
06/2014
1Inflammation (Inflammations)
01/2013
1Lung Neoplasms (Lung Cancer)
10/2012
1Marfan Syndrome (Marfan's Syndrome)
01/2012
1Hepatocellular Carcinoma (Hepatoma)
01/2012
1Breast Neoplasms (Breast Cancer)
08/2011
1Immune System Diseases (Immune Disorders)
03/2011
1Carcinoma in Situ
06/2010
1Carcinogenesis
06/2010
1Scarlet Fever
04/2008
1Fibrosarcoma
01/2007

Drug/Important Bio-Agent (IBA)

102-5A-dependent ribonuclease (RNase L)IBA
01/2020 - 01/2002
6InterferonsIBA
01/2020 - 01/2002
6Pharmaceutical PreparationsIBA
01/2020 - 08/2011
6Antiviral Agents (Antivirals)IBA
12/2014 - 01/2002
4Double-Stranded RNA (RNA, Double Stranded)IBA
10/2019 - 01/2003
4Proteins (Proteins, Gene)FDA Link
10/2014 - 01/2002
3CytokinesIBA
12/2021 - 01/2002
3Complementary DNA (cDNA)IBA
01/2007 - 01/2002
2EnzymesIBA
12/2014 - 01/2003
22',5'-oligoadenylate (PAPAPA)IBA
10/2014 - 01/2003
2nimesulide (Aulin)IBA
01/2012 - 08/2011
2Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
01/2012 - 08/2011
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2012 - 08/2011
2Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2009 - 07/2006
1Immunoglobulins (Immunoglobulin)IBA
12/2021
1GlycosaminoglycansIBA
01/2020
1ChondroitinIBA
01/2020
1Polysaccharides (Glycans)IBA
01/2020
1bleomycetinIBA
01/2020
1LigandsIBA
09/2019
1Antineoplastic Agents (Antineoplastics)IBA
09/2019
1SaltsIBA
09/2019
1CobaltIBA
09/2019
1Glucose (Dextrose)FDA LinkGeneric
11/2018
1Sucrose (Saccharose)IBA
02/2018
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
02/2018
1Mannitol (Osmitrol)FDA LinkGeneric
02/2018
1weikangningIBA
10/2017
1Sialic AcidsIBA
09/2015
1Insulin (Novolin)FDA Link
12/2014
1Poly I-CIBA
12/2014
1Streptozocin (Streptozotocin)FDA Link
12/2014
1EndoribonucleasesIBA
10/2014
1FilaminsIBA
10/2014
1GangliosidesIBA
06/2014
1Biological ProductsIBA
03/2014
1Interleukin-10 (Interleukin 10)IBA
01/2013
1Transforming Growth Factors (Transforming Growth Factor)IBA
01/2013
1Staphylococcal Protein A (Protein A)IBA
10/2012
1Messenger RNA (mRNA)IBA
10/2012
1LactamsIBA
07/2012
1Fibrillin-1IBA
01/2012
1benzo(1,3)dioxole-5-carboxylic acid (3- (2,5- dimethylbenzyloxy)- 4- (methanesulfonylmethylamino)phenyl)amideIBA
01/2012
1Bevacizumab (Avastin)FDA Link
01/2012
1Estrogen ReceptorsIBA
08/2011
1TamoxifenFDA LinkGeneric
08/2011
1Aromatase InhibitorsIBA
08/2011
1cyclohexanecarboxylic acidIBA
08/2011
1AmidesIBA
08/2011
1NeopterinIBA
03/2011
1Immunoglobulin G (IgG)IBA
03/2011
1Antimicrobial PeptidesIBA
06/2010
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
06/2010
1ChemokinesIBA
06/2010
1Chemokine ReceptorsIBA
06/2010
1Chemotactic FactorsIBA
06/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2010
1Interleukin-1alpha (Interleukin 1 alpha)IBA
06/2010
1Interleukin-8 (Interleukin 8)IBA
06/2010
1Interleukin-6 (Interleukin 6)IBA
06/2010
1Atorvastatin (Lipitor)FDA Link
05/2009
1Lovastatin (Mevacor)FDA LinkGeneric
05/2009
1AgarIBA
05/2009
1ExotoxinsIBA
04/2008
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
09/2007
1CholesterolIBA
07/2006

Therapy/Procedure

7Therapeutics
01/2021 - 04/2005
1Radiofrequency Ablation
01/2012
1Drug Therapy (Chemotherapy)
05/2009